Beilstein J. Org. Chem.2014,10, 2630–2641, doi:10.3762/bjoc.10.275
compare the efficiency of conventional and non-conventionalexperiments. All direct and competitive protocols were described and evaluated in terms of accuracy on both binding constant and inclusion enthalpy. Significant improvement in the calorimetric characterization may be obtained by means of the
global analysis of non-conventionalexperiments coupled to the standard titration protocol. While the titration-release approach proved to be the most accurate strategy for classical complexations, the valuable contribution of other non-conventionalexperiments was demonstrated for issues concerning weak
stability, enthalpy, or solubility.
Keywords: cyclodextrins; global analysis; inclusion compounds; isothermal titration calorimetry; non-conventionalexperiments; Introduction
The stability and thermodynamics of cyclodextrin inclusion compounds in solutions may be investigated with various analytical
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Graphical Abstract
Figure 1:
Non-competitive ITC isotherms for the β-CD-IBU complex at 298 K. Each protocol (from A to H) is def...